For instance, ITGB6 drives malignant behaviors in PC, with in vitro and in vivo studies demonstrating that ITGB6 knockdown suppresses proliferation, invasion, and migration of pancreatic cancer cells by disrupting TGF-β signaling and epithelial-mesenchymal transition (EMT) (27). This evidence concerns the gene ITGB6 and familial pancreatic carcinoma.