For instance, ITGB6 drives malignant behaviors in PC, with in vitro and in vivo studies demonstrating that ITGB6 knockdown suppresses proliferation, invasion, and migration of pancreatic cancer cells by disrupting TGF-β signaling and epithelial-mesenchymal transition (EMT) (27). The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.