In colon cancer, significant associations (P < 0.001; correlation coefficient ≥ 0.40) were established with markers such as CD3E, HLA-DPB1, CD3D, CD79A, TGFB1, CD2, HLA-DPA1, ITGAX, HLA-DRA, CD86, CCR7, CD19, NRP1, HAVCR2, CTLA4, and TBX21. The gene discussed is HLA-DRA; the disease is malignant colon neoplasm.