While upon admission vital signs and microvascular flow parameters did not differ between endotypes (Table 1), E1 patients were older, had more comorbidities, significantly higher C-reactive protein (CRP) and procalcitonin (PCT) levels, higher MEWS and SOFA scores, and showed more SIRS criteria (Figure 4C), indicating a more severe clinical course. This evidence concerns the gene CRP and systemic inflammatory response syndrome.