Large B-cell lymphoma (LBCL) with interferon regulatory factor 4 (<i>IRF4</i>)<i> </i>rearrangement (LBCL-<i>IRF4</i>r) is a rare type of lymphoma with an overall favorable prognosis, and has been included as a distinct entity in the 2022 revision of the World Health Organization Classification of Lymphoid Neoplasms. Here, IRF4 is linked to lymphoid neoplasm.