It means individuals with the Tel B/B genotype may have an increased risk of syphilis due to excessive NK cell activation and a pro-inflammatory environment, while, in contrast, the Tel A/B genotype includes both inhibitory (KIR3DL1 and KIR2DS4) and activating KIR genes, which are less frequent in syphilis patients (p=0.049). The gene discussed is KIR3DL1; the disease is syphilis.