T2DM, type 2 diabetes mellitus; HbA1c, hemoglobin A1c; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GTP, γ-glutamyl transpeptidase; TG, triglyceride; non-HDL-C, non-high-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate; UACR, urine albumin-to-creatinine ratio; hsCRP, high sensitive C-reactive protein; FIB-4, fibrosis 4; SGLT2i, SGLT2, sodium glucose co-transporter 2 inhibitor; GLP-1RA, glucagon-like peptide-1 receptor agonist. The gene discussed is GLP1R; the disease is diabetes mellitus.