nucleatum has been reported to promote cancer development by activating NF-κβ signaling, altering microRNA expression, modulating autophagy, and suppressing antitumor immunity,16,18,19,30,39, 40, 41 and several responsible molecules, such as FadA and Fap2, have been identified as mediators through which F. nucleatum spp. This evidence concerns the gene NFKB1 and cancer.