HDAC1 and chronic myelogenous leukemia, BCR-ABL1 positive: In this study, over-expression of MEG3 in CML cells resulted in a significant improvement in apoptosis rate, as well as a reduction in expression of several genes like DNA methyltransferases (DNMT1, DNMT3A, DNMT3B), histone deacetylase 1 (HDAC1), methyl-CpG binding domain protein 2 (MBD2), and methyl CpG binding protein 2 (MECP2) [113].