SEs refer to tissue- and cell-specific genomic domains consisting of activated enhancer clusters, that recruit core regulatory circuitry transcription factors to mediate transcriptional dysregulation in many diseases, including cancer, alcoholic hepatitis, and cardiac regeneration.23, 24, 25 It has been reported that the activity of a spinal-specific SE, located upstream of the Ntmt1 and Prrx2 genes, was significantly increased in the dorsal horn of mice with NP. This evidence concerns the gene PRRX2 and alcoholic hepatitis.