Notably, exosomes microRNA-522 (miR-522), derived from cancer-associated fibroblasts (CAFs), has been implicated in the acquisition of chemoresistance in gastric cancer (GC) cells by modulating the ALOX15 pathway and impeding lipid-ROS accumulation, as demonstrated both in vitro and in vivo (52). The gene discussed is ALOX15; the disease is gastric cancer.