In a general linear model with MDD/healthy controls as the dependent variable and cytokines, cross-sectional area of the VN, and HRV parameters as independent variables, there was only a trend for IL-1 beta (coefficient of regression 5.986, 95 % confidence interval −0.296 – 12.268, p = 0.062) to predict the state MDD/healthy control. Here, IL1B is linked to major depressive disorder.