In addition to GFAP, TSPO binding increased proportional to increased GFAP expression secondary to sepsis (Giridharan et al., 2022) and 18F-FDG PET imaging showed decreased uptake in line with reduced GFAP expression secondary to 27-hydroxycholesterol-induced cognitive impairment (Hao et al., 2023). Here, TSPO is linked to Cognitive impairment.