The secondary outcomes were to evaluate the impact on echocardiographic parameters, N-terminal pro-b-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein, MI, stroke, all-cause hospitalization and safety issues.<h4>Results</h4>From initially screened 8,922 articles, data from 6 RCTs were analysed (7,409 patients). This evidence concerns the gene CRP and Stroke.