Some studies suggested that blocking glutamine metabolism could reprogram T cell metabolism and directly activate T cells.[103] Conversely, some studies indicated that inhibiting glutaminase, while suppressing tumor growth, also disrupted the activation and antitumor capacity of dendritic cells and CD8+ T cells.[70, 104] Given that glutamine is an essential fuel for both tumor and immune cells, a key issue in this field is how to promote glutamine utilization in immune cells while inhibiting its uptake by cancer cells. This evidence concerns the gene GLS and neoplasm.