These cancers shared notable characteristics: they could take years or even decades and go through several pathological stages from precancerous lesions to invasive tumors,[85] exhibited prevalent KRAS mutations,[2] contacted with microbes through natural cavities.[86] Given the similar distributions and influential roles of microbes and KRAS mutations in tumor,[7, 86, 87] it is necessary to delineate the microbial landscape within KRAS‐mutated tumors and reflect on their crosstalk, so as to provide clues for microbe‐based precision medicine (Figure5). The gene discussed is KRAS; the disease is neoplasm.