KRAS and cancer: Upregulated CD47 in cancer cells suppressed macrophage phagocytic ability.[53] TAMs further promoted the tumorigenic transformation of KRAS G12D‐driven pancreatic intraepithelial neoplasia (PanIN) via the EGF/EGFR signaling pathway.[52, 55] Macrophages also regulated cytotoxic T cell‐mediated antitumor immunity.