U2AF1 and acute myeloid leukemia: eIF4E interacts with splice factors, e.g. PRPF6, PRPF8, PRPF19, PRPF31, SF3B1, U2AF1, U2AF2, SNRNP200 and their corresponding snRNAs (small nuclear RNA) in an RNA and cap-dependent manner in normal U2OS cells as well as in high-eIF4E AML cells, suggesting eIF4E uses its cap-binding activity to bind target mRNAs [40].