The most frequent fusion genes in AML are RUNX1::RUNX1T1, PML::RARA, ZNF292::PNRC1, NUP98::NSD1, CBFB::MYH11, KMT2A::MLLT4, KMT2A::MLT3, KMT2A::MLLT10 and DEK::NUP214 [84]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.