In MDS and AML patients, the SF mutations are associated with some other epigenetic mutations, like SF3B1 is associated with DNMT3A mutations, SRSF2 with RUNX1, IDH1/2 and ASLX1 mutations, and U2AF1 with ASXL1 and DNMT31[16]. The gene discussed is U2AF1; the disease is acute myeloid leukemia.