A comparison of nuclear eIF4E RNA immunoprecipitation (RIP)-seq data to the RNAs identified as eIF4E-dependent splicing targets in high-eIF4E AML patients revealed that ~1,300 transcripts were shared between these two groups, suggesting that all transcripts are not direct targets of eIF4E-dependent alternative splice targets. This evidence concerns the gene EIF4E and acute myeloid leukemia.