To further evaluate the functional roles of Ft–Ds–Fj module in disciplined migration, we utilized the high-mobility carcinoma cells, SKOV-3, and found that perturbation of Fj that phosphorylates the extracellular cadherin domains of both Ft and Ds and modifies their heterophilic binding (Thomas and Strutt, 2012), Ft or Ds concurrently displayed compromised directionality and reduced consistency of movement in a two-dimensional culture (Figure 5K–M, Figure 5—figure supplement 3). The gene discussed is CDH17; the disease is carcinoma.