RB1 and inclusion body myositis: KDM5A and RB1, respectively the most activated and inhibited regulators identified in our upstream analysis, are known interaction partners and through their transcriptional regulation of cell cycle and senescence, differentiation and metabolic processes, interconnect with myogenic differentiation and cellular energy homeostasis, emphasising their importance and relevance as candidate master regulators of IBM pathology [28, 29, 30].