Recently, ROS-sensitive chemical bonds, such as thioethers and thiols, have been extensively incorporated into polymer structures, enabling direct ROS scavenging for effective AKI treatment, rather than targeting oxidative stress directly [3–7], rather than directly interfering with oxidative stress targets (e.g., NOX4, GPX3, MSRA, GJB2, STC2, SESN2, NRF2, ACOX2, MAPT, HMOX1, AIFM1, etc.). The gene discussed is SESN2; the disease is acute kidney injury.