THOP1 and early-onset autosomal dominant Alzheimer disease: The most significantly enriched pathways for the different time points were G‐protein‐coupled receptor signaling (PND8), neuroprotective role of THOP1 in Alzheimer's disease (PND14), chondroitin sulfate degradation (Metazoa) (PND21), EIF2 signaling (PND35), and growth hormone signaling (PND70) (Table 2).