HK1 and Hepatic fibrosis: ChIP experiments showed that lactate treatment increased histone Kla levels at the promoters of HK1 and IDH3G, suggesting that lactate-induced H4K8la may regulate HK1 transcription [130].Meanwhile, HK2 was recently found to exert its effects via Kla rather than acetylation in liver fibrosis and a-SMA, Col1a1, and Timp1 were specific targets of Kla [22].