CD4 and neoplasm: Beyond inducing DC apoptosis, ANXA1-FPR1/3 may play other important roles in immune regulation and inflammation,40 such as modulating CD4 T cells differentiation,41 promoting M2 macrophage polarization,42 as well as inducing neutrophils and DCs apoptosis,43 as well as recruitment of DC to the tumor beds.44 Thus, the roles of ANXA1-FPR1/3 should be contextualized within the broader landscape of tumor-stroma interactions.