CD8A and neoplasm: However, dendritic cells (DCs), which are essential for the cross-presentation of antigens to CD8 T cells, exhibit markedly low infiltrated levels within the PDAC TME.16,17 Moreover, the immunosuppressive tumor-associated myeloid cells are also enriched in the TME of PDAC, further complicating the immune landscape.12,18 Collectively, these multifaceted elements contribute to the impediment of CD8 T cell infiltration, thereby maintaining the “immunologically cold” characteristics of the PDAC TME.