TLR7 and colorectal carcinoma: Among the upregulated genes in PBMCs in CRC patients are CXCL2, IL8, CCL7, CXCL3, IL10 and CCL3. Among the downregulated genes in PBMCs in CRC patients are TLR7, TLR5, TLR10, TLR8, TNFSF10 and CD79B [8].