Compared to healthy controls, 5 genes were found to be downregulated in PBMCs of all CRC patients’ groups; CCL3 (fold regulation − 6.36), IL6 (fold regulation − 12.46), CSF2 (fold regulation − 7.50), CXCR3 (fold regulation − 3.01), and TNFSF14 (fold regulation − 4.90). This evidence concerns the gene IL6 and colorectal carcinoma.