Moreover, 13 genes were upregulated in PBMCs of all CRC patients’ groups; CCR3, CD2, CD27, CD3G, CD8B, FAS, IL10, IL18R, IL5, LAG3, MAP3K7, TLR1 and TLR6. The serum levels of the four IgG subclasses were however statistically insignificant in CRC patients compared to healthy controls. This evidence concerns the gene IL18R1 and colorectal carcinoma.