An in vitro study on human pancreatic cancer cells (MIA PaCa-2) using AM251, SR141716 A, and 5-Fluorouracil showed that AM251 triggered apoptosis and altered gene transcription in the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. Here, SOAT1 is linked to pancreatic neoplasm.