METTL1/WDR4 complex can elevate m7 G modification level in tRNA through the codon-dependent manner decoded by m 7G modified tRNA, enhancing the translation of certain oncogenes such as cyclin D1/D3/E1/A2, EGFR, and vascular endothelial growth factor A (VEGFA) and promoting the progression of head and neck squamous cell carcinoma (HNSCC), lung cancer and HCC [232–235]. Here, METTL1 is linked to head and neck squamous cell carcinoma.