HMBOX1 and hepatocellular carcinoma: As an adaptor, WTAP is overexpressed in many cancers and serves as an oncogenic protein that can down-regulate the c-Myc, HMBOX1, and ETS1 mRNAs in an m6 A-mediated manner, enhancing the proliferation and metastasis of AML, osteosarcoma, and hepatocellular carcinoma (HCC) [99–102].