Sparmann and Bar-Sagi reported that activating Ras proto-oncogenes in cancer cells causes overexpression of the inflammatory cytokine interleukin-8 (IL-8) which is a powerful proinflammatory chemokine that can cause neutrophils to rapidly migrate to infection and inflammation sites, which promotes tumour inflammation, vasculogenesis, and, finally, tumour development [142]. Here, CXCL8 is linked to neoplasm.