We identified elevated levels of AXIN1 (axin1) and CASP-8 (caspase 8), proteins associated with intestinal inflammation and carcinogenesis [21, 22], as well as an increase of ST1 A1 (sulfotransferase 1 A1) in IBD group, which correlates with a recent report employing PEA multiplex technology [9]. This evidence concerns the gene CASP8 and irritable bowel syndrome.