In this context, the main objectives of the present study were to examine the impact of adding fenofibrate versus curcumin on body weight, glycemic status, lipid profile, hs-CRP, fetuin-A, and sirtuin 1 and to assess the association between fetuin-A and sirtuin 1 in patients with type 2 diabetes treated with glimepiride. Here, AHSG is linked to type 2 diabetes mellitus.