To investigate the functional role of T cells in the exacerbated IMQ-induced psoriasis under the condition of mPGES-1 deficiency, the course of IMQ-induced psoriasis in mPGES-1−/− mice was studied upon γδ T-cell depletion by treatment with an anti-TCRγδ polyclonal antibody (clone UC7-13D5) prior to the administration of IMQ (Fig. 10A). This evidence concerns the gene PTGES and psoriasis.