Furthermore, high levels of circulating antibodies were discovered in the serum of OLP patients [6]; including antibodies against Desmoglein 1 (Dsg1) and Desmoglein 3 (Dsg3) [11, 12] Desmoglein proteins are crucial for maintaining cellular cohesion in the epidermis and mucosal surfaces. The gene discussed is DSG1; the disease is oral lichen planus.