NE-SFL had superior accuracy compared to other CPD, CBC, and CRP, with 90% sensitivity and 76% specificity.<h4>Conclusions</h4>This study establishes neonatal CPD reference intervals and identifies NE-SFL as a potential sepsis biomarker.<h4>Impact</h4>This study establishes reference intervals for neonatal leukocyte Cell Population Data (CPD), providing a valuable resource for interpreting these preclinical parameters in newborns. The gene discussed is CRP; the disease is Sepsis.