Moreover, SH2B3 variants have been reported in extra-hematological pathological conditions [17, 18]; specifically, genome-wide studies have associated somatic SH2B3 polymorphisms with autoimmune diseases, including multiple sclerosis [19], type 1 diabetes [17], and systemic lupus erythematosus [17]. The gene discussed is SH2B3; the disease is systemic lupus erythematosus.