High concentrations of TNF-α are able to induce the apoptosis and necrosis of tumor cells by binding to TNFR1/2 on the tumor cell surface, whereas IFN-γ and TNF-α can inhibit the expression of Bcl-XL in tumor cells and thus increase the susceptibility of tumor cells to TRAIL-mediated apoptosis [181]. This evidence concerns the gene TNFSF10 and neoplasm.