BRAF and colorectal carcinoma: Consistent with the upregulation of pSRC expression after BRAF inhibition in BRAFV600E CRC cells, we found that SRC depletion resulted in a significantly better response to the BRAF inhibitors vemurafenib and encorafenib, pointing to SRC as one of the main critical players in the resistance mechanisms to BRAF inhibition in BRAFV600E CRC.