At a physiological level, loss of TANGO2 caused metabolic perturbances that included glucose intolerance, insulin resistance, and increased circulating levels of insulin, particularly on a high-fat diet, that have also been identified in models of desminopathy40 and muscular dystrophies41 as well as type 2 diabetes found in patients suffering from desminopathy42. Here, INS is linked to Glucose intolerance.