INS and type 2 diabetes mellitus: In T2DM, insulin is frequently prescribed to be used alongside most other non-insulin diabetes medicines, including (but not limited to) sodium–glucose cotransporter 2 (SGLT-2) inhibitors, oral and s.c. glucagon-like peptide 1 or glucagon-like peptide 1/glucose-dependent insulinotropic polypeptide receptor agonists.