NPY and obesity due to melanocortin 4 receptor deficiency: Using TRAP-seq analysis, we revealed the molecular identity of these neurons and discovered how their translational profile dynamically changes under high fat diet (HFD) or a combined HFD with stress (HFDS) conditions, providing crucial insights into how Npy neurons originating from the CeAm undergo functional gene remodelling and subsequently influence stress combined with high fat diet induced feeding behavior and obesity development.