To investigate whether genomic instability is more important in tumors with PKB upregulation, we analyzed breast cancer genomic databases in cBioPortal and found that upregulation of PKB (through genomic alterations such as PI-3 kinase amplification, PTEN mutation or homozygous deletion, and PKB amplification or E17K mutation) is associated to a significant increase in the number of genomic alterations (mutations, SVs, and copy number alterations; Fig. 1D). The gene discussed is PTEN; the disease is breast cancer.