FOXO1 and metabolic dysfunction-associated steatohepatitis: Macrophage Foxo1 has recently been shown to promote liver inflammation in mice with nonalcoholic steatohepatitis.[28] In the current study, scRNAseq analysis indicated that Foxo1 signaling is activated in the macrophages of fibrotic livers and in Tgfb1+ macrophages (Figures 1H and 4G).