Furthermore, macrophage Ghsr deficiency ameliorated CCl4‐induced liver fibrosis, indicated by significant decreases in Sirius Red staining, Masson Trichrome staining, and alpha‐smooth muscle actin (αSMA) protein levels in livers (Figure 2E–G), as well as reduced macrophage infiltration, indicated by the significant reduction of Mac‐2 staining (Figure 2E–G). Here, ACTA1 is linked to Hepatic fibrosis.