Macrophage GHSR controls inflammation and TGF‐β1 expression via protein kinase A (PKA)‐mediated Forkhead box protein O 1 (Foxo1) phosphorylation at S273; Foxo1‐S273D mutation, mimicking constitutive phosphorylation of Foxo1 at S273, shows exacerbated CCl4‐induced liver inflammation and fibrosis. This evidence concerns the gene TGFB1 and Hepatitis.