LGALS3 and Hepatic fibrosis: CCl4 administration profoundly elevated levels of serum Alanine aminotransferase (ALT) and Alanine aminotransferase (AST) (Figure 1C,D), caused hepatocyte ballooning, liver fibrosis, and increased macrophage infiltration; this was evident in the staining of Hematoxylin and eosin (H&E), Sirius Red, and Mac‐2, respectively (Figure 1E,F), suggesting the potential role of macrophages in the development of liver fibrosis.