Ghrelin has been shown to have effects on injured livers, but the mediating cellular/molecular mechanism is an ongoing debate.[17, 18, 19, 20, 21] We have demonstrated that ghrelin in monocytes is a crucial regulator of wound repair.[22] Currently, it is unknown whether macrophage GHSR affects the pathogenesis and progression of liver fibrosis.[23]. This evidence concerns the gene GHRL and Hepatic fibrosis.