Our recent study revealed that GHSR, a GPCR that stimulates the activation of GTPase for signaling transduction, promotes macrophage inflammatory response and controls liver inflammation.[15] Further molecular function (MF) analysis of these DEGs revealed the correlation of GTPase activation with liver fibrosis (Figure 1H), suggesting a potential activation of GHSR signaling by CCl4 treatment. The gene discussed is GHSR; the disease is Hepatic fibrosis.