FOXO1 and Hepatic fibrosis: Indeed, inhibition of Foxo1 by either resveratrol or Foxo1 inhibitors have shown a protective effect in iron overload‐induced liver fibrosis.[39] Moreover, anti‐oxidant Esculetin reduces TGF‐β1 expression and ameliorates HFD‐induced liver fibrosis in rats in a Foxo1‐dependent manner.[40]