These studies predominately investigated the two main subpopulations of blood DCs that are classified according to their surface markers, namely conventional or classical (cDCs; lin- CD11c+ HLD-DR+, CD123lo; a.k.a. myeloid DCs) and plasmacytoid DCs (pDCs; lin- CD11c- HLD-DR+, CD123hi) [135]: cDCs can influence different types of responses, from tolerance/regulation (e.g., induction of Tregs) to innate and/or adaptive (Th1, Th2, Th17, T follicular helper cells, cytotoxic T lymphocytes) immune responses [137] pDCs are known for their capacity to produce type I interferons upon infection. The gene discussed is ITGAX; the disease is infection.