Furthermore, in a study performed on peripheral blood and CSF, subpopulation analysis of innate immune cells using immune cell profiling by multiparameter FACS [128] revealed a shift in cell proportions from classical monocytes (defined as CD14+CD16-) to non-classical monocytes (CD14+CD16+) in the CSF of PD vs control individuals, but no differences in peripheral blood. Here, CD14 is linked to Parkinson disease.