TP53 and cancer: ALDH is higher in both subtypes of DTP cells than in parental cells, and ALDH levels affect ROS, DNA‐protein adducts, and p53 signaling, all of which can lead to more aggressive, recurrent, and drug‐resistant cancers.[15] The DTP cells exhibited an aging phenotype with slow proliferation, G1 phase arrest of the cell cycle, and increased cellular oxidative stress levels.