MRGPRD and liver cancer: Methylation and mRNA expression correlation analysis indicated that the expression levels of CEDGs correlated negatively with their methylation level, and only ANO1 in liver cancer (LIHC), BLCA, ESCA, SKCM, HNSC, LUSC, UVM, PAAD, LUAD, CESC, KIRP and COAD; GAL in LUSC, SARC, LUAD and PRAD; LRP5 in TGCT and PRAD; and MRGPRD in SARC showed a positive correlation between methylation and gene expression (S11B Fig).