All significant univariate variables were then subjected to multivariate logistic regression analysis, which demonstrated that APACHE II (OR = 1.116, 95% CI 1.073–1.161, P < 0.001), S100A9 (OR = 1.001, 95% CI 1.000–1.001, P < 0.001) and Lactate (OR = 1.212, 95% CI 1.042–1.409, P = 0.013) were independent risk factors for septic shock(Table 2). This evidence concerns the gene S100A9 and Shock.