To clarify whether S100A9 could be used as an independent risk factor for predicting sepsis death, a one-way regression analysis was first performed, which showed that APACHE II score, S100A9 level, lactate value, PCT, and IL-6 all showed a significant positive correlation with the risk of patient death, and all of them reached the level of statistical significance (P < 0.05). Here, S100A9 is linked to Sepsis.