In Hela, MDA-MB-231, U-87, and the HNSCC cell lines HN13 and CAL27, inhibiting protein synthesis led to a rapid decline in YAP and TAZ protein levels, dropping to below half within 2–4 hours (Fig 2A–C; S3A and B Fig). The gene discussed is WWTR1; the disease is head and neck squamous cell carcinoma.