Consistent with a role of FAT1 in promoting YAP/TAZ protein degradation, YAP/TAZ protein levels were less affected by protein synthesis inhibition in the FAT1-deficient HNSCC CAL33 (Fig 2D), whereas expression of FAT1ICD in CAL33 cells reduced YAP/TAZ protein levels and led to further increased protein degradation after cycloheximide treatment (Fig 2D). Here, FAT1 is linked to head and neck squamous cell carcinoma.