F2 and nephrotic syndrome: Patients with nephrotic syndrome (N=47) had significantly increased thrombin generation markers compared with healthy individuals, as indicated by elevated prothrombin fragment 1+2 (509 pmol/L, 95% confidence interval [CI], 426 to 592 versus 183 pmol/L; 95% CI, 171 to 196; P < 0.001) and thrombin-antithrombin complex (3.5 μg/L, 95% CI, 3.2 to 3.8 versus 2.5 μg/L; 95% CI, 2.3 to 2.7; P < 0.001).