TAT and Hypoalbuminemia: Disruption of the glomerular filtration barrier leads to urinary loss of antithrombin and other coagulation proteins, tipping the balance toward coagulation activation.38 At the same time, hypoalbuminemia reduces plasma oncotic pressure, which stimulates hepatic synthesis of procoagulant factors, further enhancing thrombin generation.39 Our findings of elevated F1+F2, TAT, and ETP are consistent with such pathophysiology.