CD40LG and acute coronary syndrome: The soluble form of CD40L (sCD40L) is a 18-kDa functional trimer shed from activated cells that circulates in the bloodstream exerting biological effects on the vasculature: sCD40L is a negative prognostic factor among healthy individuals [12] and patients with acute coronary syndromes, and it is an independent predictor of re-stenosis after percutaneous transluminal angioplasty [13, 14].