Given that EZH2 plays a crucial role in renal cell carcinoma by directly binding to the LATS1 promoter to inhibit its expression and promote tumor growth [22], we hypothesized that the protective effects of ZLD1039 in UUO-induced renal fibrosis might be mediated by LATS1 expression and activation. Here, EZH2 is linked to hereditary clear cell renal cell carcinoma.