EGFR and clear cell adenocarcinoma: Given that DNA methylation profiling clusters MEC with hyalinizing clear cell carcinoma (HCCC), shared CpG island hypermethylation patterns may silence pluripotency genes in both malignancies, while MENA potentially regulates DNA methyltransferase activity contributing to epigenome remodeling and histone deacetylase complexes may interact with MENA to establish repressive chromatin architecture.