Deletion of the PTEN gene in hippocampal neurons results in the overactivation of the PI3 K-AKT/mTOR signaling cascade, a key regulator of neuronal development, synaptic plasticity, and memory-related processes (Lugo et al. 2014).Aberrations in this pathway have been implicated in a range of behavioral and neurochemical abnormalities, including repetitive behaviors, increased anxiety, social interaction difficulties, and disruptions in serotonin transmission (Beaulieu et al. 2009). Here, AKT1 is linked to Anxiety.