PIK3CA and hemorrhage: Other than the presence of PIK3CA mutations, older age (≥ 35 years, median age at diagnosis) (p = 0.015), single lesions (p = 0.030), presentation of hemorrhage at diagnosis (p = 0.030), and lesions located in the brainstem or spinal cord (p = 0.011) were significantly associated with a shorter period between CM diagnosis and the first hemorrhage (figure and table, Online Resource 10 and 11).