PDCD10 and cerebral cavernous malformation: Increased expression of ECM genes in CCM3 KO human brain microvascular pericytes and augmented deposition of fibronectin and collagen in mice with mural cell-specific deletion of Ccm3 (Ccm3smKO) have previously been shown to contribute to the dissociation of ECs and pericytes in CCM lesions [85].